REPLY™ DR pacemaker

Natural Intelligence

The REPLY DR pacemaker promotes natural heart function by utilizing an intelligent algorithm to reduce unnecessary pacing in the right ventricle while effectively treating all types of AV Block.

SafeR™ 99.9% intrinsic conduction¹

• Reduces unnecessary pacing
  - 99.9% intrinsic conduction¹
  - Manages all types of AV Block

• 10-year longevity in the world’s smallest pacemaker²
  - 8cc, 10 years of longevity²

• Easy, intelligent follow-up
  - SmartCheck^TM
  - 5 minutes of dual channels A & V EGM
  - AV blocks documentation in AIDA memories

The majority of study results show that...

Unnecessary ventricular pacing increases the risk of atrial fibrillation and heart failure hospitalization³.

Clinical Results: AV Hysteresis vs. SafeR

SafeR ensures 99.9% intrinsic conduction¹.

Reduces Unnecessary Ventricular Pacing:

• SafeR significantly reduced ventricular pacing to a mean of 0.5% and a median of less than 0.1% (n=127) in patients selected for no persistent high degree AV block.⁴

• 90% of sinus node disease (SND) and 70% of paroxysmal AVB patients had less than 0.5% pacing (n=117)⁵

DPLUS™ Automatic AV Hysteresis

• Dplus automatically searches for intrinsic conduction, preserving ventricular rhythm
• Dplus significantly reduces ventricular pacing⁶

Acceleration manages Vasovagal Syncope and Carotid Sinus Syndrome

• Identifies abrupt cardiac rhythm drops and responds by an accelerated pacing of the heart and AV delay shortening

Technical Specs

• Pacing Mode: SafeR inside
• Size: 8 cc
• Longevity: 10 years²
• AF Prevention Algorithms: Overdriving, Pause Supression, PAC Acceleration
• Rate Response: Dual sensor (minute ventilation, accelerometer)
• EGM: 5 min, A and V
• Diagnosis: Automatic data analysis with programming advice

SMARTVIEW : Easy Intelligent Follow-Up

Patient follow-up is a simple three-step process using SMARTVIEW™ 
1. Interrogate and get COMPLETE data analysis
2. Run ALL sensing and pacing thresholds with SmartCheck
3. End session, print summary and save FULL report

Intended uses, indications, contraindications

For instructions on how to connect a lead to a pacemaker, download the video here 

Refer to user’s manual furnished with the device for complete instructions for use.
1. Anselme, F., et al. First clinical results of AAIsafeR2 a new mode to prevent ventricular pacing. Heart Rhythm 2005; 2, supp 5; p4-99 (abs).
2. 100% A pacing, 1% V pacing, 70 bpm, 2.5 V, 0.35 ms, 500 Ω, EGM on, Diagnostics Sensors ON, 10.3 years longevity
3. Sweeney M et al. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial to pacemaker therapy for sinus node dysfunction. Circulation 2003; 107:2932-2937.
4. Davy JM et al. Determining the optimal pacing mode to prevent ventricular pacing: SAVE R study results. Heart Rhythm 2006; 3, supp 5, S169, P2-94 (abs).
5. Defaye P et al. Impact of pacing indication on AAIsafeR2: efficacy to suppress ventricular pacing, Europace 2006; 8 supp 1, 223-4 (abs).
6. Himmrich et al. Support of spontaneous atrioventicular conduction in patients with DDD(r) pacemakers: effectiveness and safety. Herz 2001; 26(1): 69-74.

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